Paper Details

Synthesis and Antimicrobial Studies of Metal Complexes Derived from Schiff Base 1-Phenyl-2,4-Dithiobiurets and AI Applications

Vol. 11, Issue 1, Special Issue, Jan-Dec 2025 | Page: 32-34

Dr. Mayuri R Joshi
Associate Professor, Department of Chemistry, Maharashtra College of Arts, Science and Commerce, Mumbai, India

Received: 12-01-2025, Accepted: 12-02-2025, Published Online: 24-02-2025


. Download Full Paper

Abstract

Artificial Intelligence (AI) has significantly advanced the field of chemistry, providing powerful tools for research, discovery, and optimization. Key applications include drug discovery and development, predicting molecular properties, virtual screening, and material science. AI also enhances spectroscopic data analysis, facilitating molecular structure and functional group identification. This study focuses on the synthesis and spectroscopic characterization of metal complexes derived from Schiff bases. The Schiff bases were synthesized by condensing isonitroso acetophenone (HINAP) with dithiobiurets. The characterization of these complexes was performed using elemental analysis, molar conductivity, IR, electronic thermal analysis, and UV-visible spectroscopy. Antimicrobial activity was tested against Escherichia coli, Staphylococcus, Bacillus cereus, and Bacillus subtilis. Conductivity measurements indicated the non-electrolytic nature of the complexes. Thermal studies showed that they are thermally stable, insoluble in water, and soluble in organic solvents. Spectral analysis suggested an octahedral geometry for the metal complexes, further confirmed by electronic absorption and diffuse reflectance spectra.

References

  1. Cholera M. K., Thakkar N. V., (1996).Studies on Metal Complexes of Some Chelating Oximes, Ph.D. dissertation, Dept. of Chemistry, Mumbai Univ., India.
  2. A.S. Pradhan,Ph.D. Thesis, University of Bombay (1983).
  3. Chapman Hall ,Dictionary of Organic ,Compound A : 01013
  4. . W.J. Geary Coord. Chem. Rev., 7, 81 (1971)..
  5. R.G. Deshmukh and N.V. Thakkar J. Ind. J. Chem., 24, 1066 (1985).
  6. A.B.P Lever ,Inorg.Electronic Spectroscopy, Elsevier, N.Y. (1968).
  7. B.J. Hathaway and D.E. Billing , Coord. Chem. Rev., 5, 143 (1970).
  8. B.N. Figgis Introduction to Ligand Field., Wiley Interscience, N.Y. (1966).
  9. N.J. Patel and B.C. Halder, J inorg. Nucl. Chem., 29, 1037 (1967).
  10. R.L. Carlin Transition Metal Chem. Vol. I, M. Dekker Inc. New York (1965).
  11. J. Reedijk, "Metal complexes of bidentate Schiff bases," Coordination Chemistry Reviews, vol. 93, no. 1, pp. 45-66, 1989.
  12. S. Chandra, "Recent advances in oxime-based transition metal complexes and their potential biological applications," Coordination Chemistry Reviews, vol. 251, no. 1-2, pp. 127-151, 2007.